PUBLICATIONS

 

75)   R. Powers* (2009) "Drug Discovery by Screening NMR Chemical Shift Changes for Protein-Ligand Interactions" in Ligand binding and ligand screening by NMR. Istvan Pelczer, ed., Oxford University Press, Oxford, UK. in press. 

 

74)   M. T. Werth, S. Halouska, M. D. Shortridge, B. Zhang and R. Powers* (2009) "Improved Analysis of Metabolomic PCA Data using Tree Diagrams.", Analytical Biochemistry, accepted with revisions.

 

73)    R. Powers* (2009) "Advances in Nuclear Magnetic Resonance for Drug Discovery.", Expert Opinion on Drug Discovery, 4(10):1-22


72)    M. D. Shortridge and R. Powers* (2009) "Structural and Functional Similarity between the Bacterial Type III Secretion System Needle Protein PrgI and the Eukaryotic Apoptosis Bcl-2 Proteins." PLoS ONE, 4(10):1-10


71)    K. A. Mercier, G. A. Mueller, T. B. Acton, R. Xiao, G. T. Montelione, R. Powers* (2009) "1H, 13C, and 15N NMR assignments for the Bacillus subtilis yndB START domain", Biomolecular NMR Assignments, published online.


70)     R. Powers* (2009) "NMR Metabolomics and Drug Discovery.", Magnetic Resonance in Chemistry, published online.

 

69)     G. T. Montelione, C. Arrowsmith, M. E. Girvin, M. A. Kennedy, J. L. Markley, R. Powers, J. H. Prestegard, and T. Szyperski (2009) "Unique Opportunities for NMR Methods in Structural Genomics.", Journal of Structural and Functional Genomics,10:101-106.

68)    K. A. Mercier, J. R. Cort, M. Kennedy, E. E. Lockert, S. Ni, M. D. Shortridge, and R. Powers* (2009) "Structure and Function of Pseudomonas aeruginosa protein PA1324 (21-170)" Protein Science, 18(3):606-618.

67)    K. A. Mercier, M. D. Shortridge and R. Powers* (2009) "A Multi-Step NMR Screen for the Identification and Evaluation of Ligands Binding to Protein Targets.", Combinatorial Chemistry & High Throughput Screening, 12(3):285-295.

66)    S. Halouska, Y. Zhou, D. F. Becker and R. Powers* (2009) "Solution Structure of the Pseudomonas putida protein PpPutA45 and its DNA Complex." PROTEINS: Struct. Funct. Bioinformatics, 73:12-27.

 

65)    M.R. Sadykov, M. E. Olson, S. Halouska, Y. Zhu, P. D. Fey, R. Powers, and G. A. Somerville (2008) "Tricarboxylic acid cycle dependent regulation of Staphylococcus epidermidis polysaccharide intercellular adhesin synthesis". Journal of Bacteriology, 130(23):7621-7632.

64)   M. D. Shortridge, D. S. Hage, G. S. Harbison and R. Powers* (2008) "Estimating Protein-Lig and Binding Affinity using High-Throughput Screening by NMR," Journal of Combinatorial Chemistry, 10(6):948-958.

63)    J. Stark and R. Powers* (2008) "Rapid Prediction of Protein-Ligand Co-structures by Combining NMR Chemical Shift Perturbations with AutoDock", Journal of the American Chemical Society, 130(2):535-545.

 

62)    R. Powers*, J. Copeland and K. Mercier (2008) "The Application of FAST-NMR for the Identification of Novel Drug Discovery Targets.", Drug Discovery Today, 13(3-4):172-179.

 

61)    R. Powers* (2007) "Functional Genomics and NMR Spectroscopy", Combinatorial Chemistry & High Throughput Screening, 10(8):676-697.

 

60)     S. Halouska, O. Chacon, R. Fenton, D. Zinniel, R. Barletta, and R. Powers* (2007) "Use of NMR Metabolomics to Analyze the Targets of D-cycloserine in Mycobacteria: Role of D-Alanine Racemase", Journal of Proteome Research, 6(12):4608-4614.

 

59)    X. Huang, R. Espina, R. Powers and V. Roongta (2007) "Introduction to NMR and its Application in Metabolite Structure Determination" in Introduction to Drug Metabolism. Role and Practice in Drug Discovery. Donglu Zhang, ed., Wiley, Hoboken, NJ, ISBN: 978-0-471-73313-3.

 

58)    K. A. Mercier, M. Baran, V. Ramanathan, P. Revesz, R. Xiao, G. T. Montelione and R. Powers* (2006) "FAST-NMR - Functional Annotation Screening Technology Using NMR." Journal of the American Chemical Society, 128(47):15292-15299.

 

57)    P. Forgue, S. Halouska, M. Werth, K. Xu, S. Harris and R. Powers* (2006) "NMR Metabolic Profiling of Aspergillus nidulans to Monitor Drug and Protein Activity.", Journal of Proteome Research, 5(8):1916-1923.

 

56)    K.A. Mercier, K. Germer and R. Powers* (2006) "Design and Characterization of a Functional Library for NMR Screening against Novel Protein Targets.", Combinatorial Chemistry & High Throughput Screening, 9(7):515-534.

 

55)    R. Powers*, J. Copeland, K. Germer, K. A. Mercier, V. Ramanathan and P. Revesz (2006) "Comparison of Protein Active-Site Structures for Functional Annotation of Proteins and Drug Design." PROTEINS: Struct. Funct. Bioinformatics, 65(1):124-135.

 

54)    Y-J., Huang, R. Tejero, R. Powers and G. T. Montelione (2006) "A topology-constrained distance network algorithm for protein structure determination from NOESY data." PROTEINS: Struct. Funct. Bioinformatics, 62(3):587-603.

 

53)    S. Halouska and R. Powers* (2006) "Negative Impact of Noise on the Principal Component Analysis of NMR Data." Journal of Magnetic Resonance, 178(1):88-95. supplement.

 

52)   R. Powers and M. M. Siegel (2006) "Applications of Nuclear Magnetic Resonance and Mass Spectrometry to Anticancer Drug Discovery." in Novel Anticancer Agents: Strategies for Discovery and Clinical Testing. A. A. Adjei and J. K. Buolamwini, eds., Elsevier Science, New York, NY, ISBN: 0-12-088561-1.

 

51)   V. Ramanathan, K. A. Mercier, R. Powers, and P. Revesz (2005) "Using Databases and Computational Techniques to Infer the Function of Novel Proteins." 2005 IEEE International Conference on Electro Information Technology (On CD, collection of reviewed papers).

 

50)   R Powers,* N. Mirkovic, D. Murray, S. Goldsmith-Fischman, T. B. Acton, Y. Chiang, R. Paranji, J. R. Cort, J. Y. Huang, M. A. Kennedy, J. Liu, L. Ma, B. Rost and G. T. Montelione (2005) "Solution Structure of Archaeglobus fulgidis Peptidyl-tRNA Hydrolase (Pth2) Provides Evidence for an Extensive Conserved Family of Pth2 Enzymes in Archea, Bacteria and Eukaryotes." Protein Science, 14(11):2849-2861 (cover).

 

49)   Y. J. Huang, R. Powers, and G. T. Montelione (2005) "Protein NMR Recall, Precision, and F-measure Scores (RPF scores): Structure Quality Assessment Measures Based on Information Retrieval Statistics." Journal of the American Chemical Society, 127(6):1665-1674.

 

48)   Y. J. Huang, H. Moseley, M. C. Baran, C. Arrowsmith, R. Powers, R. Tejero, T. Szyperski, and G. T. Montelione (2005) "An Integrated Platform for Automated Analysis of Protein NMR Structures." Methods in Enzymology, 394:111-141.

 

47)   K. A. Mercier and R. Powers* (2005) "Determining the Optimal Size of Small Molecule Mixtures for High Throughput NMR Screening." Journal of Biomolecular NMR, 31(3):243-258.

 

46)   R. Powers*, T. B. Acton, Y. Chiang, R. Paranji, J. R. Cort, M. A. Kennedy, J. Liu, L. Ma, B. Rost and G. T. Montelione (2004) "Letter to the Editor: 1H, 13C and 15N Assignments for the Archaeglobus fulgidis Protein  AF2095." Journal of Biomolecular NMR, 30:107-108.

 

45)   D. Shao, T. J. Berridon, E. Manas, D. Hauze, R. Powers, A. Bapat, D. Gonder, R. C. Winneker and D. Frail (2004) "Identification of Novel Estrogen Receptor a Antagonists."  J. Steroid biochem Mol. Biol, 88(4-5):351-360.

 

44)   T. Rush III and R. Powers* (2004) "The Application of X-ray, NMR and Molecular Modeling in the Design of MMP Inhibitors." Current Topics in Medicinal Chemistry, 4 (12):1311-1327.

 

43)   F. J. Moy, P. K. Chanda, J. Chen, S. Cosmi, W. Edris, J. I. Levin, J. Wilhelm and R. Powers* (2002) "Impact of Mobility on Structure-Based Drug Design for the MMPs." Journal of the American Chemical Society, 124(43):12658-12659. supp1, supp2.

 

42)   R. Powers* (2002) "Applications of NMR to Structure Based Drug Design in Structural Genomics." Journal of Structural and Functional Genomics, 2:113-123.

 

41)   F. J. Moy, E. Diblasio, J. Wilhelm and R. Powers* (2001) "Solution Structure of Human IL-13  and Implication for Receptor Binding" Journal of Molecular Biology, 310(1):219-230.

 

40)   J. I. Levin, M. T. Du, J. F. DiJoseph, L. M. Killar, A. Sung, A, T. Walter, M. A. Sharr, C. E. Roth, F. J. Moy, R. Powers, G. Jin, R. Cowling, J. S. Skotnicki, (2001) "The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position." Bioorg. Med. Chem. Lett., 11(2):235-238.

 

39)   X. Huang and R. Powers* (2001) "Validity of Using the Radius of Gyration as a Constraint in NMR Protein Structure Determination." Journal of the American Chemical Society, 123(16):3834-3835.

 

38)   G.-Y. Xu, A. Tam, L. Lin and R. Powers* (2001) "Solution Structure of B. subtillis Acyl carrier protein" Structure, 9(4):277-287.

 

37)   S. F. Sukits, L.-L. Lin, S. Hsu, K. Malakian, R. Powers and G. Y. Xu (2001) "The solution Structure of the Tumor Necrosis Factor Receptor-1 Death Domain" Journal of Molecular Biology, 310(4):895-906.

 

36)   F. J. Moy, K. Haraki, D. Mobilio, G. Walker K. Tabei, H. Tong, M. M. Siegel and R. Powers* (2001) "MS/NMR: A Structure Based Approach for Discovering Protein Ligands and for Drug Design by Coupling Size-exclusion Chromatography, Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy" Analytical Chemistry, 73(3):571-581.

 

35)   X. Huang, F. J. Moy, and R. Powers* (2000) "Evaluation of the Utility of NMR Structures Determined from Minimal NOE Based Restraints for Structure Based Drug Design, using MMP-1 as an Example." Biochemistry, 39(44):13365-13375.

 

34)   F. J. Moy, P. K. Chanda, J. M. Chen, S. Cosmi, W. Edris, J. I. Levin and R. Powers* (2000) "High-Resolution Solution Structure of the Catalytic Fragment of Human Collagenase-3 (MMP-13) Complexed with a Hydroxamic acid Inhibitor" Journal of Molecular Biology, 302(3):673-691.

 

33)   J. M. Chen, J. I. Levin, D. Mobilio, F. J. Moy, F. C. Nelson, R. Nilakantan, Arie Z. and R. Powers* (2000) "Structure Based Design of a Novel, Potent and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer Aided Molecular Design" Journal of the American Chemical Society, 122(40):9648-9654.

 

32)   J.-B. Telliez, G.-Y. Xu, J. Woronicz, S. Hsu, L. Lin, S. F Sukits, R. Powers and L.-L. Lin (2000) "Mutational Analysis and NMR studies of the Death Domain of the Tumor Necrosis Factor Receptor 1" Journal of Molecular Biology, 300(5):1323-1333.

 

31)   S. A. Desai, X. Wang, E. J. Noronha, Q. Zhou, V. Rebmann, H. Grosse-Wilde, F. J. Moy, R. Powers, and S. Ferrone (2000) "Structural Relatedness of Distinct Determinants Recognized by Monoclonal Antibody TP25.99 on b2-Microglobulin-associated and b2-microglobulin-free HLA Class I Antigens." Journal of Immunology, 165(6):3275-3283.

 

30)   F. J. Moy, S. A. Desai, X. Wang, E. J. Noronha, Q. Zhou, S. Ferrone, R. Powers* (2000) "Analysis by NMR Spectroscopy of mAb TP25.99 Defined Linear and Conformational Determinant on HLA Class I Antigen." Journal of Biological Chemistry, 275(32):24679-24685.

 

29)   F. J. Moy, E. Glasfeld, L. Mosyak and R. Powers* (2000) "Solution Structure of ZipA, a Crucial Component of E. coli Cell Division" Biochemistry, 39(31):9146-9156.

 

28)   F. J. Moy, P. K. Chanda, S. Cosmi, W. Edris J. I. Levin and R. Powers* (2000) "1H, 15N, 13C, and 13CO Assignments and Secondary Structure Determination of Collagenase-3 (MMP-13) Complexed with a Hydroxamic Acid Inhibitor" Journal of Biomolecular NMR, 17(3):269-270. MMP13_693_assignment table.doc

 

27)   F. J. Moy, E. Glasfeld and R. Powers* (2000) "1H, 15N, 13C, and 13CO Assignments and Secondary Structure Determination of ZipA" Journal of Biomolecular NMR, 17(3):275-276. ZipA-assignment-table.doc

 

26)   F. J. Moy, P. K. Chanda, M. I. Cockett, W. Edris, P. G. Jones, K. Mason, S. Semus and R. Powers* (2000) "NMR Structure of Free RGS4 Reveals an Induced Conformational Change Upon Binding Ga." Biochemistry, 39(24):7063-7073.

 

25)   F. J. Moy, P. K. Chanda, M. I. Cockett, W. Edris., P. G. Jones, and R. Powers* (1999) "1H, 15N, 13C, and 13CO Assignments and Secondary Structure Determination of RGS4." Journal of Biomolecular NMR, 15:339-340. RGS4-assignment-table.doc

 

24)   F. J. Moy, P. K. Chanda, J. M. Chen, S. Cosmi, W. Edris, J. S. Skotnicki, J. Wilhelm and R. Powers* (1999) "NMR Solution Structure of the Catalytic Fragment of Human Fibroblast Collagenase Complexed with a Sulfonamide Derivative of a Hydroxamic Acid Compound." Biochemistry 38(22):7085-7096.

 

23)   R. Tejero, D. Monleon, B. Celda, R. Powers and G. T. Montelione (1999) "HYPER: A Hierarchical Algorithim Involving Progressive Application of Conformational Constraints For Automatic Determination of Protein Dihedral-Angle Constraints and CbH2 Methylene Resonance Assignments from NMR Data." J. Biomol. NMR, 15:251-264.

 

22)   D. Kitchen, R. C. Hoffman, F. J. Moy, and R. Powers* (1998) "Homology Model for Oncostatin M Based on NMR Structural Data." Biochemistry, 37(30):10581-10588.

 

21)   F. J. Moy, P. K. Chanda, C. Urbano, M. R. Pisano, J. Wilhelm and R. Powers* (1998) "High-Resolution Solution Structure of the Inhibitor-Free Catalytic Fragment of Human Fibroblast Collagenase" Biochemistry, 37(6):1495-1504.

 

20)   F. J. Moy, M. R. Pisano, P. K. Chanda, C. Urbano, L. M. Killar, M.-L. Sung and R. Powers* (1997) "Assignments, Secondary Structure and Dynamics of the Inhibitor-Free Catalytic Fragment of Human Fibroblast Collagenase" Journal of Biomolecular NMR, 10:9-19. MMP-1 Assignment Table

 

19)   D. E. Zimmerman, C. A. Kulikowski, W. Feng,M. Tashiro, C.-Y. Chien, C. B. Rios, F. J. Moy, R. Powers, G. T. Montelione (1997) "Automated Analysis of Protein NMR Assignments Using Methods from Artificial Intelligence" J. Mol. Biol., 269:592-610.

 

18)   F. J. Moy, M. Safran, A. P. Seddon, D. Kitchen, P. Bohlen, D. Aviezer, A. Yayon, and R. Powers* (1997) "Properly Oriented Heparin-Decasaccharide Induced Dimers are the Biological Active Form of Basic Fibroblast Growth Factor" Biochemistry, 36(16):4782-4791.

 

17)   F. J. Moy, A. P. Seddon, P. Bohlen and R. Powers* (1996) "High-Resolution Solution Structure of Basic Fibroblast Growth Factor Determined by Multidimensional Heteronuclear Magnetic Resonance Spectroscopy" Biochemistry, 35 42):13552-13561.

 

16)   R. C. Hoffman, F. J. Moy, V. Price, J. Richardson, D. Kaubisch, E. A. Frieden, J. D. Krakover, B. J. Castner, J. King, C. J. March, and R. Powers* (1996) "Resonance Assignments for Oncostatin M: a 24 kDa a-Helical Protein." Journal of Biomolecular NMR, 7:273-282. Onco M assignment tbl

 

15)   F. J. Moy, A. P. Seddon, E. B. Campbell, P. Bhlen and R. Powers* (1995) "1H, 15N, 13C, and 13CO Assignments and Secondary Structure Determination of Basic Fibroblast Growth Factor Using Three-Dimensional Heteronuclear Magnetic Resonance Spectroscopy." Journal of Biomolecular NMR, 6:245-254. sFGF assignment table.doc

 

14)   R. Powers, G. M. Clore, D. S. Garrett, and A. M. Gronenborn (1993) "Relationship between the Precision of High-Resolution Protein NMR Structures, Solution-Order Parameters, and Crystallographic B Factors." Journal of   Magnetic Resonance, Series B, 101(3):325-327.

 

13)   R. Powers, D. S. Garrett, C. J. March, E. A. Frieden, A. M. Gronenborn, and G. Marius Clore (1993) "The High-Resolution, Three-Dimensional Solution Structure of Human Interleukin-4 Determined by Multidimensional Heteronuclear Magnetic Resonance Spectroscopy." Biochemistry, 32(26):6744-6762.

 

12)   G. W. Vuister, G. M. Clore, A. M. Gronenborn, R. Powers, D. S. Garrett, R. Tschudin, and A. Bax (1993) "Increased Resolution and Improved Spectral Quality in Four-Dimensional 13C/13C-Separated HMQC-NOESY-HMQC Spectra using Pulsed Field Gradients." Journal of Magnetic Resonance, Series B., 101(2):210-213.

 

11)   R. Powers*, G. M. Clore, and A. M. Gronenborn (1992) "Analysis of the Backbone Dynamics of the Ribonuclease H Domain of the Human Immunodeficiency Virus Reverse Transcriptase by Two-Dimensional Inverse Detected Heteronuclear 15N-1H NMR Spectroscopy." Biochemistry, 31(38):9150-9157.

 

10)  R. Powers, D. S. Garrett, C. J. March, E. A. Frieden, A. M. Gronenborn, and G. M. Clore (1992) "Three-Dimensional Solution Structure of Human Interleukin-4 by Multi-Dimensional Heteronuclear Magnetic Resonance Spectroscopy" Science, 256:1673-1677.

 

9)    D. S. Garrett, R. Powers, C. J. March, E. A. Frieden, G. M. Clore, and A. M. Gronenborn (1992) "Determination of the Secondary Structure and Folding Topology of Human Interleukin-4 using Three-Dimensional Heteronuclear Magnetic Resonance Spectroscopy" Biochemistry, 31(17):4347-4353.

 

8)    R. Powers, D. S. Garrett, C. J. March, E. A. Frieden, A. M. Gronenborn, and G. M. Clore (1992) "1H, 15N, 13C, and 13CO Assignments of Human Interleukin-4 using Three-Dimensional Double and Triple Resonance Heteronuclear Magnetic Resonance Spectroscopy" Biochemistry, 31(17):4334-4346.

 

7)    D. S. Garrett, R. Powers, A. M. Gronenborn, and G. M. Clore (1991) " A Common Sense Approach to Peak Picking Two-, Three- and Four-Dimensional Spectra using Automatic Computer Analysis of Contour Diagrams." Journal of Magnetic Resonance, 95:214-220.

 

6)     R. Powers, G. M. Clore, A. Bax, D. S. Garrett, S. J. Stahl, P. T. Wingfield, and A. M. Gronenborn (1991) " Secondary Structure of the Ribonuclease H Domain of the Human Immunodeficiency Virus Reverse Transcriptase in Solution using Three-Dimensional Double and Triple Resonance Heteronuclear Magnetic Resonance Spectroscopy." Journal of Molecular Biology, 221:1081-1090.

 

5)     R. Powers, A. M. Gronenborn, G. M. Clore, and A. Bax (1991) "Three-Dimensional Triple Resonance NMR of 13C/15N Enriched Proteins using Constant-Time Evolution." Journal of Magnetic Resonance, 94:209-213.

 

4)     R. Powers and D. G. Gorenstein (1990) "Two-Dimensional 1H and 31P NMR Spectra and Restrained Molecular Dynamics Structure of a Covalent CPI-CDPI2 Oligodeoxyribonucleotide Decamer Complex." Biochemistry, 29(42):9994-10008.

 

3)     R. Powers, C. R. Jones, and D. G. Gorenstein (1990) "Two-Dimensional 1H and 31P NMR Spectra and Restrained Molecular Dynamics Structure of an Oligodeoxyribonucleotide Duplex Refined via a Hybrid Relaxation Matrix Procedure." Journal of Biomolecular Structure & Dynamics, 8(2):253-294.

 

2)     R. Powers, R. K. Olsen, and D. G. Gorenstein (1989) "Two-Dimensional 1H and 31P NMR Spectra of a Decamer Oligodeoxyribonucleotide Duplex and a Quinoxaline ([N-MeCys 3, N-MeCys 7]TANDEM) Drug Duplex Complex." Journal of Biomolecular Structure & Dynamics, 7(3):515-556.

 

1)    V. Roongta, R. Powers, C. Jones, J. Shields, and D. G. Gorenstein (1988) "Solution Conformation of a Synthetic Fragment of Human Pituitary Growth Hormone; Two Dimensional NMR of an Alpha-Helical Dimer." Biochemistry, 28(3):1048-1055.